Luisa Moretto, Steven Vance, Brennan Heames and R. William Broadhurst
Chem. Commun., 2017,53, 11457-11460
DOI:
10.1039/C7CC04625A,
Communication
Open Access Learn more..Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5′-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.
