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Issue 68, 2017
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Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant

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Abstract

We utilize the supramolecular self-assembling peptide of Nap-GDFDFDYDK to construct chemically programmed, self-assembling and self-adjuvant MUC1-based antitumor vaccines. The vaccines, with antigen and adjuvant conjugation through covalent bonds, elicited both humoral and cellular immune responses.

Graphical abstract: Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant

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Article information


Submitted
06 Jun 2017
Accepted
01 Aug 2017
First published
01 Aug 2017

Chem. Commun., 2017,53, 9486-9489
Article type
Communication

Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant

Y. Liu, Y. Wang, F. Yu, Z. Zhang, Z. Yang, W. Zhang, P. G. Wang and W. Zhao, Chem. Commun., 2017, 53, 9486
DOI: 10.1039/C7CC04386D

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