Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 68, 2017
Previous Article Next Article

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Author affiliations

Abstract

Aggregation of the highly amyloidogenic IAPP is endogenously inhibited inside beta-cell granules at millimolar concentrations. Combining in vitro experiments and computer simulations, we demonstrated that the stabilization of IAPP upon the formation of zinc-coordinated ion molecular complex with C-peptide might be important for the endogenous inhibition of IAPP aggregation.

Graphical abstract: Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Back to tab navigation

Supplementary files

Article information


Submitted
02 Jun 2017
Accepted
19 Jul 2017
First published
19 Jul 2017

Chem. Commun., 2017,53, 9394-9397
Article type
Communication

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

X. Ge, A. Kakinen, E. N. Gurzov, W. Yang, L. Pang, E. H. Pilkington, P. Govindan-Nedumpully, P. Chen, F. Separovic, T. P. Davis, P. C. Ke and F. Ding, Chem. Commun., 2017, 53, 9394
DOI: 10.1039/C7CC04291D

Social activity

Search articles by author

Spotlight

Advertisements