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Issue 51, 2017
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Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters

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Abstract

Cobaloxime (Co(dmgBF2)2·2H2O), an inexpensive first-row transition-metal complex, catalyzed hydration of terminal alkynes gave the corresponding methyl ketones in good to excellent yields under neutral conditions (additional protic acids and silver salts are not required). A wide range of functional groups, such as allyl ether, benzyl ethers, carboxylic esters, imides, amides, nitro, and halogens, were tolerated. The mild reaction conditions together with the inexpensive feature and easy availability of the catalyst well address the current challenges in the field of alkyne hydration.

Graphical abstract: Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters

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Article information


Submitted
20 May 2017
Accepted
06 Jun 2017
First published
06 Jun 2017

Chem. Commun., 2017,53, 6926-6929
Article type
Communication

Cobaloxime-catalyzed hydration of terminal alkynes without acidic promoters

S. Hou, H. Yang, B. Cheng, H. Zhai and Y. Li, Chem. Commun., 2017, 53, 6926
DOI: 10.1039/C7CC03919K

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