Issue 57, 2017
From the journal:

Chemical Communications

A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells†

Liping Qiu,ab   Florian Wimmers, ORCID logo b   Jorieke Weiden, ORCID logo b   Hans A. Heus,c   Jurjen Tel ORCID logo ‡*bde  and  Carl G. Figdor ORCID logo ‡*b  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

b Department of Tumor Immunology, Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
E-mail: Carl.Figdor@radboudumc.nl

c Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands

d Department of Biomedical Engineering, Laboratory of Immunoengineering, Eindhoven University of Technology, Eindhoven, The Netherlands
E-mail: J.Tel@tue.nl

e Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

Abstract

Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the detection of cytokines secreted by single cells using a combination of aptamer-based sensors and droplet microfluidics.

Graphical abstract: A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

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Article information

DOI
https://doi.org/10.1039/C7CC03576D
Article type
Communication
Submitted
08 May 2017
Accepted
21 Jun 2017
First published
26 Jun 2017
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2017,53, 8066-8069

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A membrane-anchored aptamer sensor for probing IFNγ secretion by single cells

L. Qiu, F. Wimmers, J. Weiden, H. A. Heus, J. Tel and C. G. Figdor, Chem. Commun., 2017, 53, 8066 DOI: 10.1039/C7CC03576D

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