Lipid radicals cause light-induced retinal degeneration

Masataka Enoki; Saki Shinto; Yuta Matsuoka; Ayasa Otsuka; Sachiko Kaidzu; Masaki Tanito; Takahiro Shibata; Koji Uchida; Akihiro Ohira; Mayumi Yamato; Ken-ichi Yamada

doi:10.1039/C7CC03387G

Lipid radicals cause light-induced retinal degeneration†

Masataka Enoki,‡^a Saki Shinto,‡^a Yuta Matsuoka,^a Ayasa Otsuka,^a Sachiko Kaidzu,^b Masaki Tanito,^b Takahiro Shibata,^cd Koji Uchida,^e Akihiro Ohira,^b Mayumi Yamato^a and Ken-ichi Yamada

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^a Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan
E-mail: kenyamada@phar.kyushu-u.ac.jp

^b Department of Ophthalmology, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane, Japan

^c Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences and School of Agricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, Japan

^d Japan Science and Technology Agency, PRESTO, 4-1-8 Hon-cho, Kawaguchi, Saitama, Japan

^e Laboratory of Food Chemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

Chemical Communications

Lipid radicals cause light-induced retinal degeneration†

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Lipid radicals cause light-induced retinal degeneration

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