Issue 46, 2017

Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

Abstract

A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin–GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI–toxin binding.

Graphical abstract: Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

Supplementary files

Article information

Article type
Communication
Submitted
20 Apr 2017
Accepted
15 May 2017
First published
15 May 2017

Chem. Commun., 2017,53, 6227-6230

Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins

J. Gao, Z. Zhou, J. Guo and Z. Guo, Chem. Commun., 2017, 53, 6227 DOI: 10.1039/C7CC03056H

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