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Issue 47, 2017
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Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

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Abstract

Tuning molecular structures of self-assembling multivalent (SAMul) dendritic cationic lipopeptides controls the self-assembled morphology. In buffer, spherical micelles formed by higher generation systems bind polyanionic heparin better than worm-like micelles formed by lower generation systems. In human serum, the binding of spherical micelles to heparin is adversely affected, while worm-like micelles maintain their relative binding ability.

Graphical abstract: Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

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Supplementary files

Article information


Submitted
19 Apr 2017
Accepted
23 May 2017
First published
30 May 2017

Chem. Commun., 2017,53, 6335-6338
Article type
Communication

Morphological control of self-assembled multivalent (SAMul) heparin binding in highly competitive media

A. C. Rodrigo, S. M. Bromfield, E. Laurini, P. Posocco, S. Pricl and D. K. Smith, Chem. Commun., 2017, 53, 6335 DOI: 10.1039/C7CC02990J

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