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Issue 37, 2017
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Foscarnet calcium microcrystals as the intravitreal drug depot

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Abstract

Foscarnet sodium is an antiviral drug for the treatment of CMV retinitis, currently in the form of twice-weekly intravitreal injection. Here we developed foscarnet calcium microcrystals as the drug depot, and using the rabbit model we demonstrated that the injected microcrystals maintained a therapeutically relevant drug concentration in the vitreous for more than 3 months.

Graphical abstract: Foscarnet calcium microcrystals as the intravitreal drug depot

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Article information


Submitted
29 Mar 2017
Accepted
13 Apr 2017
First published
13 Apr 2017

Chem. Commun., 2017,53, 5139-5142
Article type
Communication

Foscarnet calcium microcrystals as the intravitreal drug depot

Y. Sun, Y. Tao, Q. Cao and Y. Huang, Chem. Commun., 2017, 53, 5139
DOI: 10.1039/C7CC02399E

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