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Issue 39, 2017
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The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells

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Abstract

New fluorogenic sensors with suitable kinetic parameters and sensitivity have been developed for the determination of sphingosine-1-phosphate lyase activity in cell lysates. The probe RBM148 can be efficiently loaded into cationic liposomes and used to determine S1PL activity in intact cells.

Graphical abstract: The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells

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Supplementary files

Article information


Submitted
03 Mar 2017
Accepted
23 Apr 2017
First published
24 Apr 2017

Chem. Commun., 2017,53, 5441-5444
Article type
Communication

The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells

P. Sanllehí, M. Casasampere, J. Abad, G. Fabriàs, O. López, J. Bujons, J. Casas and A. Delgado, Chem. Commun., 2017, 53, 5441
DOI: 10.1039/C7CC01659J

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