Issue 36, 2017
From the journal:

Chemical Communications

A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation†

Nanami Kikuchia  and  Dmitry M. Kolpashchikov ORCID logo *abc  

* Corresponding authors

a Chemistry Department, University of Central Florida, Orlando, Florida, USA

b Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA

c National Center for Forensic Science, University of Central Florida, Orlando, FL, USA
E-mail: dmk2111@gmail.com, dmitry.kolpashchikov@ucf.edu

Abstract

We demonstrate how a single universal spinach aptamer (USSA) probe can be used to detect multiple (potentially any) nucleic acid sequences. USSA can be used for cost-efficient and highly selective analysis of even folded DNA and RNA analytes, as well as for the readout of outputs of DNA logic circuits.

Graphical abstract: A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation

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Article information

DOI
https://doi.org/10.1039/C7CC01540B
Article type
Communication
Submitted
27 Feb 2017
Accepted
10 Apr 2017
First published
10 Apr 2017

Chem. Commun., 2017,53, 4977-4980

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A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation

N. Kikuchi and D. M. Kolpashchikov, Chem. Commun., 2017, 53, 4977 DOI: 10.1039/C7CC01540B

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