Issue 34, 2017
From the journal:

Chemical Communications

One-step colorimetric detection of an antibody based on protein-induced unfolding of a G-quadruplex switch†

Xiaolu Hu,‡a   Chao Li,‡a   Chang Feng,a   Xiaoxia Mao,b   Yang Xiang*a  and  Genxi Li ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China
E-mail: xiangy@nju.edu.cn, genxili@nju.edu.cn

b Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Abstract

A simple colorimetric assay is developed for the sensitive and selective detection of an antibody, which combines a protein binding-induced signaling approach with a novel DNAzyme-based conformational switching strategy.

Graphical abstract: One-step colorimetric detection of an antibody based on protein-induced unfolding of a G-quadruplex switch

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Article information

DOI
https://doi.org/10.1039/C7CC00687J
Article type
Communication
Submitted
24 Jan 2017
Accepted
29 Mar 2017
First published
29 Mar 2017

Chem. Commun., 2017,53, 4692-4694

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One-step colorimetric detection of an antibody based on protein-induced unfolding of a G-quadruplex switch

X. Hu, C. Li, C. Feng, X. Mao, Y. Xiang and G. Li, Chem. Commun., 2017, 53, 4692 DOI: 10.1039/C7CC00687J

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