Issue 22, 2017
From the journal:

Chemical Communications

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy†

Min Guo,a   Hui-Jing Xiang,a   Yi Wang,b   Qian-Ling Zhang,*b   Lu An,c   Shi-Ping Yang,c   Yinchu Ma,d   Yucai Wangd  and  Jin-Gang Liu ORCID logo *a  

* Corresponding authors

a Key Lab for Advanced Materials of MOE, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, P. R. China
E-mail: liujingang@ecust.edu.cn

b Shenzhen Key Lab of Functional Polymer, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, P. R. China
E-mail: zhql@szu.edu.cn

c Key Lab of Resource Chemistry of MOE & Shanghai Key Lab of Rare Earth Functional Materials, Shanghai Normal University, Shanghai, P. R. China

d School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, P. R. China

Abstract

A mitochondria-targeting nanoplatform for near-infrared-light-controlled release of nitric oxide accompanied by photothermal therapy was developed, which consists of ruthenium nitrosyl functionalized N-doped graphene quantum dots and a triphenylphosphonium moiety. The nanoplatform demonstrated both in vitro and in vivo anti-tumor efficacy upon irradiation with 808 nm light.

Graphical abstract: Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C7CC00670E
Article type
Communication
Submitted
24 Jan 2017
Accepted
24 Feb 2017
First published
24 Feb 2017

Chem. Commun., 2017,53, 3253-3256

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Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

M. Guo, H. Xiang, Y. Wang, Q. Zhang, L. An, S. Yang, Y. Ma, Y. Wang and J. Liu, Chem. Commun., 2017, 53, 3253 DOI: 10.1039/C7CC00670E

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