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Issue 29, 2017
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Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

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Abstract

We design and synthesize EpCAM antibodies with Fc-domain site-specific linkers that allow preferential alignment when coated on microfluidic devices for capturing circulating tumor cells (CTCs) from colorectal cancer patients. The aligned coating is shown to increase the capture efficiency of CTCs and microemboli by 1.6 and 3.0-fold, respectively (both P < 0.05).

Graphical abstract: Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

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Article information


Submitted
12 Jan 2017
Accepted
15 Mar 2017
First published
17 Mar 2017

Chem. Commun., 2017,53, 4152-4155
Article type
Communication

Site-specific antibody modification and immobilization on a microfluidic chip to promote the capture of circulating tumor cells and microemboli

C. Lai, S. Choon Lim, L. Wu, C. Wang, W. Tsai, H. Wu and Y. Chang, Chem. Commun., 2017, 53, 4152
DOI: 10.1039/C7CC00247E

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