Issue 20, 2017
From the journal:

Chemical Communications

An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification†

Ying Zhang,a   Lixu Wang,a   Fang Luo, ORCID logo *b   Bin Qiu,a   Longhua Guo, ORCID logo a   Zuquan Weng,*b   Zhenyu Lina  and  Guonan Chena  

* Corresponding authors

a Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Fuzhou University, Fuzhou, Fujian, China

b College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350116, China
E-mail: luofang0812@163.com, wengzq@fzu.edu.cn

Abstract

Herein, an electrochemiluminescence (ECL) biosensor for ultrasensitive and specific detection of Kras mutant genes has been developed on the basis of the high discrimination capability of locked nucleic acid (LNA) and dual signal amplification techniques including DNA walkers and hyperbranched rolling circle amplification (HRCA).

Graphical abstract: An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification

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Article information

DOI
https://doi.org/10.1039/C7CC00009J
Article type
Communication
Submitted
02 Jan 2017
Accepted
26 Jan 2017
First published
26 Jan 2017

Chem. Commun., 2017,53, 2910-2913

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An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification

Y. Zhang, L. Wang, F. Luo, B. Qiu, L. Guo, Z. Weng, Z. Lin and G. Chen, Chem. Commun., 2017, 53, 2910 DOI: 10.1039/C7CC00009J

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