A new simple protocol, using TMSNTf2 or Tf2NH as the catalyst, for the activation of trichloroacetimidate donors is described. This O-glycosylation proceeds with stereospecific inversion of the donor configuration. The scope of the protocol has been investigated using common glycosyl donors reacting with simple alcohols as well as sugar acceptors.
K. Kowalska and C. M. Pedersen, Chem. Commun., 2017, 53, 2040 DOI: 10.1039/C6CC10076G
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