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Issue 10, 2017
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Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy

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Abstract

Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.

Graphical abstract: Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy

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The article was received on 28 Nov 2016, accepted on 04 Jan 2017 and first published on 04 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09473B
Citation: Chem. Commun., 2017,53, 1680-1683
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    Inner salt-shaped small molecular photosensitizer with extremely enhanced two-photon absorption for mitochondrial-targeted photodynamic therapy

    W. Hu, T. He, R. Jiang, J. Yin, L. Li, X. Lu, H. Zhao, L. Zhang, L. Huang, H. Sun, W. Huang and Q. Fan, Chem. Commun., 2017, 53, 1680
    DOI: 10.1039/C6CC09473B

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