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Issue 32, 2017

Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

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Abstract

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.

Graphical abstract: Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

Supplementary files

Article information


Submitted
24 Nov 2016
Accepted
21 Mar 2017
First published
22 Mar 2017

Chem. Commun., 2017,53, 4509-4512
Article type
Communication

Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

D. Limón, C. Jiménez-Newman, A. C. Calpena, A. González-Campo, D. B. Amabilino and L. Pérez-García, Chem. Commun., 2017, 53, 4509 DOI: 10.1039/C6CC09392B

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