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Issue 11, 2017
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Fluorogenic probes to monitor cytosolic phospholipase A2 activity

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Abstract

Arachidonic acid derivatives equipped with either one or two fluorescent groups attached to the tip of the alkyl chains were synthesized and shown to function as inhibitor and substrate probes of cPLA2. The inhibitor probe was demonstrated to perform dual functions of inhibition and imaging while the substrate probe could be used for activity assay.

Graphical abstract: Fluorogenic probes to monitor cytosolic phospholipase A2 activity

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Publication details

The article was received on 22 Nov 2016, accepted on 09 Jan 2017 and first published on 17 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09305A
Chem. Commun., 2017,53, 1813-1816

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    Fluorogenic probes to monitor cytosolic phospholipase A2 activity

    C. Y. Ng, T. X. W. Kwok, F. C. K. Tan, C. Low and Y. Lam, Chem. Commun., 2017, 53, 1813
    DOI: 10.1039/C6CC09305A

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