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Issue 17, 2017
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Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity

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Abstract

We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.

Graphical abstract: Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity

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Publication details

The article was received on 10 Nov 2016, accepted on 03 Feb 2017 and first published on 03 Feb 2017


Article type: Communication
DOI: 10.1039/C6CC08978J
Citation: Chem. Commun., 2017,53, 2618-2621
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    Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity

    H. Wang, J. Wu, L. Xu, K. Xie, C. Chen and Y. Dong, Chem. Commun., 2017, 53, 2618
    DOI: 10.1039/C6CC08978J

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