Issue 3, 2017

Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation

Abstract

A novel fluorescent photoaffinity probe of OSW-1 was prepared in two steps from a naturally occurring inactive congener by a sequential site-selective acylation strategy using Me2SnCl2. It displayed highly potent anticancer activity and a similar intracellular localization property to that of a fluorescently-tagged OSW-1, thereby demonstrating its potential utility in live cell studies.

Graphical abstract: Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
09 Nov 2016
Accepted
24 Nov 2016
First published
02 Dec 2016

Chem. Commun., 2017,53, 517-520

Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation

K. Sakurai, M. Hiraizumi, N. Isogai, R. Komatsu, T. Shibata and Y. Ohta, Chem. Commun., 2017, 53, 517 DOI: 10.1039/C6CC08955K

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