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Issue 3, 2017
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Easy access to triazolinedione-endcapped peptides for chemical ligation

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Abstract

An efficient and easy route towards triazolinedione (TAD) endcapped peptides is described, in which a TAD-precursor was coupled to N-terminal amines on a solid support. Modified peptides readily reacted with diene end-functionalized poly(ε-caprolactone) of different molecular weights. The ligation proved to be orthogonal to a variety of functional groups present in natural amino acids.

Graphical abstract: Easy access to triazolinedione-endcapped peptides for chemical ligation

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Submitted
28 Oct 2016
Accepted
07 Dec 2016
First published
07 Dec 2016

Chem. Commun., 2017,53, 593-596
Article type
Communication

Easy access to triazolinedione-endcapped peptides for chemical ligation

P. Wilke, T. Kunde, S. Chattopadhyay, N. ten Brummelhuis, F. E. Du Prez and H. G. Börner, Chem. Commun., 2017, 53, 593
DOI: 10.1039/C6CC08683G

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