Solid-state NMR at natural isotopic abundance for the determination of conformational polymorphism – the case of designed β-turn peptides containing di-prolines

Abstract

The proton double quantum–carbon single quantum correlation experiment has been applied to designed peptides in the solid state in natural isotopic abundance. Analogous to nOe studies in solution, through-space double-quantum connectivities have been exploited to obtain the cis–trans conformational polymorphism of diproline residues occurring at β-turns in the peptides.