Issue 2, 2017

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Abstract

Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labelling of Annexin V. The Annexin V-BASHY conjugate maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.

Graphical abstract: Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

Supplementary files

Article information

Article type
Communication
Submitted
28 Oct 2016
Accepted
25 Nov 2016
First published
30 Nov 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 368-371

Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

P. M. S. D. Cal, F. Sieglitz, F. M. F. Santos, C. Parente Carvalho, A. Guerreiro, J. B. Bertoldo, U. Pischel, P. M. P. Gois and G. J. L. Bernardes, Chem. Commun., 2017, 53, 368 DOI: 10.1039/C6CC08671C

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