Issue 11, 2017

Cobalt-catalyzed aryl C–H activation and highly regioselective intermolecular annulation of sulfonamides with allenes

Abstract

Herein we describe a cobalt-catalyzed C–H activation of aryl and heteroaryl sulfonamides and their intermolecular heteroannulation reaction with allenes, providing a convergent strategy for the synthesis of biologically interesting heterocyclic scaffolds. Carbometallation of allenes proceeds selectively through a Co-alkenyl pathway for a wide range of electron-poor and electron-rich allenes.

Graphical abstract: Cobalt-catalyzed aryl C–H activation and highly regioselective intermolecular annulation of sulfonamides with allenes

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2016
Accepted
14 Jan 2017
First published
16 Jan 2017

Chem. Commun., 2017,53, 1872-1875

Cobalt-catalyzed aryl C–H activation and highly regioselective intermolecular annulation of sulfonamides with allenes

N. Thrimurtulu, R. Nallagonda and C. M. R. Volla, Chem. Commun., 2017, 53, 1872 DOI: 10.1039/C6CC08622E

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