Issue 5, 2017

Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide

Abstract

We report here a supramolecular strategy to assemble a cyclodextrin-functionalized anticancer Ru(II) complex with an adamantane-appended tumor-targeting peptide into discrete and stable phosphorescent nanostructures that can induce cell death in integrin αvβ3-rich tumor cells with high selectivity. This strategy presents new opportunities for the construction of tumor-targeting metallo-anticancer therapeutics.

Graphical abstract: Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2016
Accepted
24 Nov 2016
First published
24 Nov 2016

Chem. Commun., 2017,53, 842-845

Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-β-cyclodextrin complex and an adamantane-functionalized peptide

S. Xue, C. Tan, M. Chen, J. Cao, D. Zhang, R. Ye, L. Ji and Z. Mao, Chem. Commun., 2017, 53, 842 DOI: 10.1039/C6CC08296C

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