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Issue 31, 2017
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From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

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Abstract

Dihydroceramide desaturase 1 (Des1) catalyzes the last step of ceramide synthesis de novo, thus regulating the physiologically relevant balance between dihydrosphingolipids and sphingolipids. Here we report on the configurational preference of Des1 towards isomeric Δ6-unsaturated dihydroceramide analogs and the discovery of a potent Des1 inhibitor.

Graphical abstract: From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

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Article information


Submitted
13 Oct 2016
Accepted
27 Mar 2017
First published
27 Mar 2017

Chem. Commun., 2017,53, 4394-4397
Article type
Communication

From the configurational preference of dihydroceramide desaturase-1 towards Δ6-unsaturated substrates to the discovery of a new inhibitor

A. Pou, J. Abad, Y. F. Ordóñez, M. Garrido, J. Casas, G. Fabriàs and A. Delgado, Chem. Commun., 2017, 53, 4394
DOI: 10.1039/C6CC08268H

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