Issue 1, 2017
From the journal:

Chemical Communications

Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles†

Hai Huang,a   Hongdong Shi,a   Jing Liu,b   Yuanzeng Min,c   Yucai Wang,b   Andrew Z. Wang,c   Jun Wangb  and  Yangzhong Liu ORCID logo *a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

b School of Life Sciences, University of Science and Technology of China, China

c Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Co-delivery of all-trans-retinoic acid and paclitaxel using albumin-bound nanoparticles demonstrated a significantly improved anti-metastatic effect to breast cancer both in vitro and in vivo. Notably, the co-delivery nanoparticles exhibited more pronounced therapeutic effects than the combination of two free drugs or two HSA loaded single drugs.

Graphical abstract: Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles

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Article information

DOI
https://doi.org/10.1039/C6CC08146K
Article type
Communication
Submitted
09 Oct 2016
Accepted
23 Nov 2016
First published
05 Dec 2016

Chem. Commun., 2017,53, 212-215

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Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles

H. Huang, H. Shi, J. Liu, Y. Min, Y. Wang, A. Z. Wang, J. Wang and Y. Liu, Chem. Commun., 2017, 53, 212 DOI: 10.1039/C6CC08146K

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