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Issue 1, 2017
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Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

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Abstract

The HIV nucleocapsid NCp7–SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for “non-covalent” molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent “fixation” by Au–Cys bond formation providing a chemotype for a new distinct class of nucleocapsid–nucleic acid antagonist.

Graphical abstract: Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

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Supplementary files

Article information


Submitted
02 Oct 2016
Accepted
09 Nov 2016
First published
09 Nov 2016

Chem. Commun., 2017,53, 91-94
Article type
Communication

Au(III) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

S. R. Spell, J. B. Mangrum, E. J. Peterson, D. Fabris, R. Ptak and N. P. Farrell, Chem. Commun., 2017, 53, 91 DOI: 10.1039/C6CC07970A

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