Issue 8, 2017

Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

Abstract

Optimization of cell-material interactions is crucial for the success of synthetic biomaterials in guiding tissue regeneration. To do so, catechol chemistry is often used to introduce adhesiveness into biomaterials. Here, a supramolecular approach based on ureido-pyrimidinone (UPy) modified polymers is combined with catechol chemistry in order to achieve improved cellular adhesion onto supramolecular biomaterials. UPy-modified hydrophobic polymers with non-cell adhesive properties are developed that can be bioactivated via a modular approach using UPy-modified catechols. It is shown that successful formulation of the UPy-catechol additive with the UPy-polymer results in surfaces that induce cardiomyocyte progenitor cell adhesion, cell spreading, and preservation of cardiac specific extracellular matrix production. Hence, by functionalizing supramolecular surfaces with catechol functionalities, an adhesive supramolecular biomaterial is developed that allows for the possibility to contribute to biomaterial-based regeneration.

Graphical abstract: Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2017
Accepted
06 Jun 2017
First published
13 Jun 2017
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2017,5, 1541-1548

Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

S. Spaans, P. P. K. H. Fransen, B. D. Ippel, D. F. A. de Bont, H. M. Keizer, N. A. M. Bax, C. V. C. Bouten and P. Y. W. Dankers, Biomater. Sci., 2017, 5, 1541 DOI: 10.1039/C7BM00407A

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