Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Qing Pei; Xiuli Hu; Junli Zhou; Shi Liu; Zhigang Xie

doi:10.1039/C7BM00052A

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Glutathione-responsive paclitaxel dimer nanovesicles with high drug content†

Qing Pei,^ab Xiuli Hu,^a Junli Zhou,^ab Shi Liu^a and Zhigang Xie

*^a

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* Corresponding authors

^a State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: xiez@ciac.ac.cn
Fax: +86 431 85262775
Tel: +86 431 85262775

^b University of Science and Technology of China, Hefei 230026, P. R. China

Abstract

Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.

This article is part of the themed collection: Emerging Investigators 2017

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Article information

DOI: https://doi.org/10.1039/C7BM00052A
Article type: Communication
Submitted: 18 Jan 2017
Accepted: 02 Feb 2017
First published: 13 Feb 2017

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Biomater. Sci., 2017,5, 1517-1521

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Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Q. Pei, X. Hu, J. Zhou, S. Liu and Z. Xie, Biomater. Sci., 2017, 5, 1517 DOI: 10.1039/C7BM00052A

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Biomaterials Science

Glutathione-responsive paclitaxel dimer nanovesicles with high drug content†

Abstract

Supplementary files

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Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

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