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Issue 7, 2017
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NMR-based metabolomics strategies: plants, animals and humans

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Abstract

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical platform employed to address a diversity of issues of research such as in understanding chemical reaction mechanisms and chemical kinetics, and characterization and elucidation of small and macromolecules, among many others. In the last few decades and with the advancement of biotechnology, NMR has been widely employed in metabolomics where it has greatly contributed to the agricultural, veterinary, medicinal and pharmacological fields in the search for biomarkers of diseases. This Tutorial Review addresses the principal steps (sample preparation, acquisition and processing of spectra, data analysis and biomarker discovery) and methodologies used in NMR-based metabolomics applied for pointing to key metabolites of diseases.

Graphical abstract: NMR-based metabolomics strategies: plants, animals and humans

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Article information


Submitted
15 Nov 2016
Accepted
03 Jan 2017
First published
04 Jan 2017

Anal. Methods, 2017,9, 1078-1096
Article type
Tutorial Review

NMR-based metabolomics strategies: plants, animals and humans

J. G. M. Pontes, A. J. M. Brasil, G. C. F. Cruz, R. N. de Souza and L. Tasic, Anal. Methods, 2017, 9, 1078
DOI: 10.1039/C6AY03102A

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