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Issue 14, 2017
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A label-free electrochemical bisphenol A immunosensor based on chlorogenic acid as a redox probe

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Abstract

A simple and sensitive electrochemical immunosensor for bisphenol A was prepared with an acetylene black–chitosan–gold composite (AB–CS–Au) and gold nanoparticles (AuNPs) as electrode modifiers and chlorogenic acid (CGA) as the redox probe. AB–CS–Au acted as a signal amplifier and anti-BPA was immobilized at the modified electrode using AuNPs to capture bisphenol A in a sample solution. After some factors such as pH of the supporting electrolyte and immunoreaction time were optimized, a quantitative detection of bisphenol A was established in the range of 7.5 × 10−9−1.0 × 10−6 M with a limit of detection (LOD) and quantitation (LOQ) of 6.4 × 10−9 M (3 σ/k) and 2.1 × 10−8 M (10 σ/k), respectively. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were applied to characterize the construction procedures of the immunosensor. The ascribed immunosensor yielded good results in terms of specificity, stability and reproducibility and was successfully applied to sample analysis with accuracy.

Graphical abstract: A label-free electrochemical bisphenol A immunosensor based on chlorogenic acid as a redox probe

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Article information


Submitted
02 Nov 2016
Accepted
04 Mar 2017
First published
06 Mar 2017

Anal. Methods, 2017,9, 2183-2188
Article type
Paper

A label-free electrochemical bisphenol A immunosensor based on chlorogenic acid as a redox probe

X. Li, Y. Huang, M. Chen, Y. Tong and C. Zhang, Anal. Methods, 2017, 9, 2183
DOI: 10.1039/C6AY02997C

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