Novel ipratropium bromide nanomaterial based screen-printed sensors

Abstract

Screen printing technology offers a simple and reproducible fabrication protocol for large scale production of sensors. Herein, sensitive disposable sensors have been constructed for the potentiometric determination of ipratropium bromide (IPBr) using a carbon nanotubes/β-cyclodextrin nanocomposite (CNTs/β-CD) as a molecular recognition element. The electrode matrix composition was optimized on the basis of the nature and content of the electroactive material, ionic sites, membrane plasticizer and nanomaterial. The proposed sensors showed remarkable selectivity and sensitivity in the ipratropium concentration range from 10⁻⁶ to 10⁻² mol L⁻¹ with a Nernstian slope of 61.4 ± 0.5 mV per decade and detection limit of 2.5 × 10⁻⁷ mol L⁻¹. Modification with the CNTs/β-CD nanocomposite as a sensing material enhanced the stability of potential reading, response time and shelf lifetime of the fabricated sensors. The proposed method was successfully applied for the potentiometric assay of IPBr in dosage formulation and biological fluids in batch and flow injection analyses (FIA) with average recoveries agreeable with the reported official methods.