Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

K. Khaliqi; A. Ghazal; I. D. M. Azmi; H. Amenitsch; K. Mortensen; S. Salentinig; A. Yaghmur

doi:10.1039/C7AN00860K

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Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

K. Khaliqi,†^a A. Ghazal,†^ab I. D. M. Azmi,^a H. Amenitsch,^c K. Mortensen,

^b S. Salentinig

*^d and A. Yaghmur

*^a

Author affiliations

* Corresponding authors

^a Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark
E-mail: anan.yaghmur@sund.ku.dk

^b Niels Bohr Institute, University of Copenhagen, Denmark, Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark

^c Elettra-Sincrotrone Trieste, Strada Statale 14, 34149 Basovizza, Trieste, Italy

^d Laboratory for Biointerfaces, Department of Materials of Meet Life, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland
E-mail: Stefan.Salentinig@empa.ch, stefan.salentinig@gmail.com

Abstract

Lipid exchange among citrem nanoparticles and an ethanol micellar solution containing soy phosphatidylcholine was investigated in situ by coupling small angle X-ray scattering with a microfluidic device. The produced soy phosphatidylcholine/citrem nanoparticles have great potential in the development of hemocompatible nanocarriers for drug delivery.

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Article information

DOI: https://doi.org/10.1039/C7AN00860K
Article type: Communication
Submitted: 24 May 2017
Accepted: 05 Jul 2017
First published: 07 Jul 2017

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Analyst, 2017,142, 3118-3126

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Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

K. Khaliqi, A. Ghazal, I. D. M. Azmi, H. Amenitsch, K. Mortensen, S. Salentinig and A. Yaghmur, Analyst, 2017, 142, 3118 DOI: 10.1039/C7AN00860K

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Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

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Direct monitoring of lipid transfer on exposure of citrem nanoparticles to an ethanol solution containing soybean phospholipids by combining synchrotron SAXS with microfluidics

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