Jump to main content
Jump to site search

Issue 45, 2016

Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

Author affiliations

Abstract

The design of exudate-managing wound dressings is an established route to accelerated healing, although such design remains a challenge from material and manufacturing standpoints. Aiming towards the clinical translation of knowledge gained in vitro with highly-swollen rat tail collagen hydrogels, this study investigated the healing capability in a diabetic mouse wound model of telopeptide-free, protease-inhibiting collagen networks. 4-Vinylbenzylation and UV irradiation of type I atelocollagen (AC) led to hydrogel networks with chemical and macroscopic properties comparable to previous collagen analogues, attributable to similar lysine content and dichroic properties. After 4 days in vitro, hydrogels induced nearly 50 RFU% reduction in matrix metalloproteinase (MMP)-9 activity, whilst showing less than 20 wt% mass loss. After 20 days in vivo, dry networks promoted 99% closure of 10 × 10 mm full thickness wounds and accelerated neo-dermal tissue formation compared to Mepilex®. This collagen system can be equipped with multiple, customisable properties and functions key to personalised chronic wound care.

Graphical abstract: Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

Supplementary files

Article information


Submitted
02 Sep 2016
Accepted
17 Oct 2016
First published
18 Oct 2016

J. Mater. Chem. B, 2016,4, 7249-7258
Article type
Paper

Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

G. Tronci, J. Yin, R. A. Holmes, H. Liang, S. J. Russell and D. J. Wood, J. Mater. Chem. B, 2016, 4, 7249 DOI: 10.1039/C6TB02268E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements