Issue 46, 2016

Three-dimensional printing of tricalcium silicate/mesoporous bioactive glass cement scaffolds for bone regeneration

Abstract

Bone defects, particularly large bone defects resulting from infections, trauma, surgical resection or genetic malformations, remain a significant challenge for clinicians. In this study, the tricalcium silicate/mesoporous bioactive glass (C3S/MBG) cement scaffolds were successfully fabricated for the first time by 3D printing with a curing process, which combined the hydraulicity of C3S with the excellent biological property of MBG together. The C3S/MBG scaffolds exhibited 3D interconnected macropores (∼400 μm), high porosity (∼70%), enhanced mechanical strength (>12 MPa) and excellent apatite mineralization ability. Human bone marrow-derived mesenchymal stem cells (hBMSCs) were cultured on the scaffolds to evaluate their cell responses, and the results showed that C3S/MBG scaffolds could stimulate the attachment, proliferation and differentiation of hBMSCs with increasing MBG component. The critical-sized rat calvarial defect animal model was employed; further in vivo results indicated that both C3S and C3S/MBG30 scaffolds could induce new bone formation, but the C3S/MBG30 scaffolds significantly improved the osteogenic capacity compared to the pure C3S scaffolds. Therefore, the C3S/MBG cement scaffolds fabricated by 3D printing with a curing process would be a promising candidate for bone regeneration.

Graphical abstract: Three-dimensional printing of tricalcium silicate/mesoporous bioactive glass cement scaffolds for bone regeneration

Article information

Article type
Paper
Submitted
13 Aug 2016
Accepted
26 Oct 2016
First published
27 Oct 2016

J. Mater. Chem. B, 2016,4, 7452-7463

Three-dimensional printing of tricalcium silicate/mesoporous bioactive glass cement scaffolds for bone regeneration

P. Pei, X. Qi, X. Du, M. Zhu, S. Zhao and Y. Zhu, J. Mater. Chem. B, 2016, 4, 7452 DOI: 10.1039/C6TB02055K

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