Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 41, 2016
Previous Article Next Article

Nanoparticle delivery systems for siRNA-based therapeutics

Author affiliations

Abstract

RNA interference (RNAi) is a naturally occurring endogenous regulatory process in which the short double-stranded RNA causes sequence-specific post-transcriptional gene silencing. Small interfering RNA (siRNA) represents great therapeutic potential for diseases (e.g., cancer) caused by abnormal gene overexpression or mutation. The major challenge in using RNAi for disease therapy is the targeted and effective delivery of siRNA in vivo. The development of nanotechnology with the important progress in nanoparticle-mediated delivery systems promises efficient intracellular siRNA delivery. This review summarizes the recent advances in nanoparticle delivery systems for siRNA-based therapeutics.

Graphical abstract: Nanoparticle delivery systems for siRNA-based therapeutics

Back to tab navigation

Publication details

The article was received on 14 Jun 2016, accepted on 21 Aug 2016 and first published on 22 Aug 2016


Article type: Review Article
DOI: 10.1039/C6TB01462C
Citation: J. Mater. Chem. B, 2016,4, 6620-6639

  •   Request permissions

    Nanoparticle delivery systems for siRNA-based therapeutics

    J. Li, S. Xue and Z. Mao, J. Mater. Chem. B, 2016, 4, 6620
    DOI: 10.1039/C6TB01462C

Search articles by author

Spotlight

Advertisements