Issue 31, 2016

Mn(ii) silver-aptamer clusters for targeted MR imaging of tumors

Abstract

Hypoxia-inducible factor (HIF) highly expressed in most of the cancer cells. The Mn(II)-aptamer based nanoclusters with 3D structures would be HIF-aptamer based targeted magnetic resonance imaging agents for cancer MRI diagnosis. Herein, a new class of contrast agent Mn(II) silver-aptamer clusters (AdpaMn@DNA-Ag-DNAG1) were constructed based on the assembly of DNA-mediated Ag nanoclusters (DNA–AgNCs) with the Mn(II) complex (AdpaMn) and DNAG1, the recognition sequence of GLUT-1. Then, the Mn(II) silver-aptamer clusters (AdpaMn@DNA-Ag-DNAG1) are used as the MRI agents both in vitro and in vivo. The results show that the MRI signal is clearly presented in the tumor position. Consequently, the Mn(II) silver-aptamer clusters can be used as a new class of contrast agents for targeted MR imaging of tumors.

Graphical abstract: Mn(ii) silver-aptamer clusters for targeted MR imaging of tumors

Supplementary files

Article information

Article type
Paper
Submitted
07 May 2016
Accepted
11 Jul 2016
First published
15 Jul 2016

J. Mater. Chem. B, 2016,4, 5284-5288

Mn(II) silver-aptamer clusters for targeted MR imaging of tumors

W. Mu, X. Xiao, T. Chen and Q. Chen, J. Mater. Chem. B, 2016, 4, 5284 DOI: 10.1039/C6TB01146B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements