Jump to main content
Jump to site search

Issue 23, 2016
Previous Article Next Article

Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

Author affiliations

Abstract

The advancement of biocompatible nanoplatforms with dual functionalities of diagnosis and therapeutics has been strongly demanded in biomedicine in recent years. In this work, we report the synthesis and characterization of polydopamine (pD)-coated gold nanostars (Au NSs) for computed tomography (CT) imaging and enhanced photothermal therapy (PTT) of tumors. Au NSs were firstly formed via a seed-mediated growth method and then stabilized with thiolated polyethyleneimine (PEI-SH), followed by deposition of pD on their surface. The formed pD-coated Au NSs (Au-PEI@pD NSs) were well characterized. We show that the Au-PEI@pD NSs are able to convert the absorbed near-infrared laser light into heat, and have strong X-ray attenuation properties. Due to the co-existence of Au NSs and pD, the light to heat conversion efficiency of the NSs can be significantly enhanced. These very interesting properties allow them to be used as a powerful theranostic nanoplatform for efficient CT imaging and enhanced phtotothermal therapy of cancer cells in vitro and the xenografted tumor model in vivo. Due to their easy functionalization nature enabled by the coated pD shell, the developed pD-coated Au NSs may be used as a versatile nanoplatform for targeted CT imaging and PTT of different types of cancers.

Graphical abstract: Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Mar 2016, accepted on 16 May 2016 and first published on 16 May 2016


Article type: Paper
DOI: 10.1039/C6TB00773B
Citation: J. Mater. Chem. B, 2016,4, 4216-4226
  •   Request permissions

    Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy

    D. Li, Y. Zhang, S. Wen, Y. Song, Y. Tang, X. Zhu, M. Shen, S. Mignani, J. Majoral, Q. Zhao and X. Shi, J. Mater. Chem. B, 2016, 4, 4216
    DOI: 10.1039/C6TB00773B

Search articles by author

Spotlight

Advertisements