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Issue 16, 2016
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Triple-stimuli-responsive nanocontainers assembled by water-soluble pillar[5]arene-based pseudorotaxanes for controlled release

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Abstract

We constructed triple-stimuli-responsive nanocontainers (T-SRNs), consisting of mesoporous silica nanoparticles for accommodating cargoes and bistable [2]pseudorotaxanes for regulating cargoes and realizing controlled release. T-SRNs eliminate premature leakage of model cargoes under neutral solution conditions by the formation of complexes of water-soluble carboxylate-substituted pillar[5]arenes (WP5) with 1,6-hexanediammonium (HDA) recognition stations to block pore orifices. After exposure to acid, alkali pH or Zn2+ environments, T-SRNs release encapsulated cargoes promptly, which can be attributed to the dethreading of WP5 from HDA sites by different approaches and the lack of stoppers. The unique acid/alkali/Zn2+-responsive controlled release characteristic mean that T-SRNs have potential in some application fields. Herein, MTT assays and in vitro release of doxorubicin from T-SRNs demonstrate that T-SRNs can serve as promising targeted drug delivery vehicles.

Graphical abstract: Triple-stimuli-responsive nanocontainers assembled by water-soluble pillar[5]arene-based pseudorotaxanes for controlled release

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Publication details

The article was received on 23 Feb 2016, accepted on 16 Mar 2016 and first published on 22 Mar 2016


Article type: Paper
DOI: 10.1039/C6TB00459H
Citation: J. Mater. Chem. B, 2016,4, 2819-2827
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    Triple-stimuli-responsive nanocontainers assembled by water-soluble pillar[5]arene-based pseudorotaxanes for controlled release

    C. Ding, Y. Liu, T. Wang and J. Fu, J. Mater. Chem. B, 2016, 4, 2819
    DOI: 10.1039/C6TB00459H

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