Issue 24, 2016

Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release

Abstract

Mechanical stimulus is one of the universally accessible physical ways of triggering the drug release from their carriers. Hollow microcapsules made of polyelectrolyte multilayers by conventional methods are not elastic enough to respond to a large and repetitive mechanical deformation. Here, hybrid hollow capsules comprising alternating layers of inorganic colloidal particles and biopolymers were prepared by the layer-by-layer approach followed by freezing-assisted crosslinking of polymer layers. The size of the capsule was controllable by the size of sacrificial cores. These hybrid capsules were mechanically more stable and recover faster than polyelectrolyte capsules, and could be recovered elastically even after large and repetitive deformation up to 98% relative to their original dimensions. Drugs in a wide range of molecular weight up to 70 kDa Mw could be loaded into the hollow hybrid microcapsules and the release of loaded contents from these hybrid capsules could be controlled through the deformation by applying a weak force such as a finger pressing on them. Mechanical stimuli-responsive delivery of model drugs was demonstrated on a monolayer of these hybrid capsules.

Graphical abstract: Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release

Supplementary files

Article information

Article type
Paper
Submitted
18 Feb 2016
Accepted
03 May 2016
First published
04 May 2016

J. Mater. Chem. B, 2016,4, 4278-4286

Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release

R. Rajamanickam, S. Baek, K. Gwon, Y. Hwang, K. Shin and G. Tae, J. Mater. Chem. B, 2016, 4, 4278 DOI: 10.1039/C6TB00410E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements