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Issue 11, 2016
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A multicomponent approach for the preparation of homoallylic alcohols

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Abstract

Here we report the in situ generation of transient allylic boronic species, by reacting TMSCHN2 and E-vinyl boronic acids, followed by their subsequent trapping with aldehydes as electrophiles to yield homoallylic alcohols. This metal-free reaction was initially discovered by the use of a flow chemistry approach to generate a variety of homoallylic alcohols in a straightforward fashion and then transferred to a batch protocol.

Graphical abstract: A multicomponent approach for the preparation of homoallylic alcohols

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Article information


Submitted
12 Jun 2016
Accepted
05 Jul 2016
First published
08 Jul 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 6803-6807
Article type
Edge Article
Author version available

A multicomponent approach for the preparation of homoallylic alcohols

J. Poh, S. Lau, I. G. Dykes, D. N. Tran, C. Battilocchio and S. V. Ley, Chem. Sci., 2016, 7, 6803
DOI: 10.1039/C6SC02581A

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