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Issue 11, 2016
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A multicomponent approach for the preparation of homoallylic alcohols

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Abstract

Here we report the in situ generation of transient allylic boronic species, by reacting TMSCHN2 and E-vinyl boronic acids, followed by their subsequent trapping with aldehydes as electrophiles to yield homoallylic alcohols. This metal-free reaction was initially discovered by the use of a flow chemistry approach to generate a variety of homoallylic alcohols in a straightforward fashion and then transferred to a batch protocol.

Graphical abstract: A multicomponent approach for the preparation of homoallylic alcohols

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Publication details

The article was received on 12 Jun 2016, accepted on 05 Jul 2016 and first published on 08 Jul 2016


Article type: Edge Article
DOI: 10.1039/C6SC02581A
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Chem. Sci., 2016,7, 6803-6807
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    A multicomponent approach for the preparation of homoallylic alcohols

    J. Poh, S. Lau, I. G. Dykes, D. N. Tran, C. Battilocchio and S. V. Ley, Chem. Sci., 2016, 7, 6803
    DOI: 10.1039/C6SC02581A

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