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Issue 11, 2016
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Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

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Abstract

Hyperpolarization of metabolites by dissolution dynamic nuclear polarization (D-DNP) for MRI applications often requires fast and efficient removal of the radicals (polarizing agents). Ordered mesoporous SBA-15 silica materials containing homogeneously dispersed radicals, referred to as HYperPolarizing SOlids (HYPSOs), enable high polarization – P(1H) = 50% at 1.2 K – and straightforward separation of the polarizing HYPSO material from the hyperpolarized solution by filtration. However, the one-dimensional tubular pores of SBA-15 type materials are not ideal for nuclear spin diffusion, which may limit efficient polarization. Here, we develop a generation of hyperpolarizing solids based on a SBA-16 structure with a network of pores interconnected in three dimensions, which allows a significant increase of polarization, i.e. P(1H) = 63% at 1.2 K. This result illustrates how one can improve materials by combining a control of the incorporation of radicals with a better design of the porous network structures.

Graphical abstract: Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

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Publication details

The article was received on 11 May 2016, accepted on 15 Jul 2016 and first published on 18 Jul 2016


Article type: Edge Article
DOI: 10.1039/C6SC02055K
Citation: Chem. Sci., 2016,7, 6846-6850
  • Open access: Creative Commons BY license
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    Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

    D. Baudouin, H. A. van Kalkeren, A. Bornet, B. Vuichoud, L. Veyre, M. Cavaillès, M. Schwarzwälder, W.-C. Liao, D. Gajan, G. Bodenhausen, L. Emsley, A. Lesage, S. Jannin, C. Copéret and C. Thieuleux, Chem. Sci., 2016, 7, 6846
    DOI: 10.1039/C6SC02055K

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