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Issue 5, 2016

Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

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Abstract

A series of porphyrin–fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.

Graphical abstract: Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

Supplementary files

Article information


Submitted
31 Oct 2015
Accepted
02 Feb 2016
First published
17 Feb 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 3331-3337
Article type
Edge Article

Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

Y. Takano, T. Numata, K. Fujishima, K. Miyake, K. Nakao, W. D. Grove, R. Inoue, M. Kengaku, S. Sakaki, Y. Mori, T. Murakami and H. Imahori, Chem. Sci., 2016, 7, 3331 DOI: 10.1039/C5SC04135J

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