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Issue 1, 2016
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Electronic control of DNA-based nanoswitches and nanodevices

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Abstract

Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of these DNA-based nanodevices we have applied different voltage potentials at the surface of an electrode chip. The applied potential promotes an electron-transfer reaction that releases from the electrode surface a molecular input that ultimately triggers the DNA-based nanodevice. The use of electronic inputs as a way to finely activate DNA-based nanodevices appears particularly promising to expand the available toolbox in the field of DNA nanotechnology and to achieve a better hierarchical control of these platforms.

Graphical abstract: Electronic control of DNA-based nanoswitches and nanodevices

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Publication details

The article was received on 29 Sep 2015, accepted on 12 Nov 2015 and first published on 12 Nov 2015


Article type: Edge Article
DOI: 10.1039/C5SC03694A
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Citation: Chem. Sci., 2016,7, 66-71
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    Electronic control of DNA-based nanoswitches and nanodevices

    S. Ranallo, A. Amodio, A. Idili, A. Porchetta and F. Ricci, Chem. Sci., 2016, 7, 66
    DOI: 10.1039/C5SC03694A

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