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Issue 2, 2016
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Highly efficient and scalable chemoenzymatic syntheses of (R)- and (S)-lactaldehydes

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Abstract

Biocatalytic asymmetric reductions have been key steps in the enantioselective reduction of 1,1-dimethoxy-2-propanone, catalyzed by suitable ketoreductases, to enantiomerically pure (S)- and (R)-1,1-dimethoxy-2-propanols, obtained in ≥99.9% ee and excellent yield. Removal of the protecting group gave the (S)- and (R)-lactaldehydes in high yield and excellent enantiomeric and chemical purity.

Graphical abstract: Highly efficient and scalable chemoenzymatic syntheses of (R)- and (S)-lactaldehydes

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Article information


Submitted
04 Aug 2015
Accepted
14 Oct 2015
First published
06 Nov 2015

React. Chem. Eng., 2016,1, 156-160
Article type
Communication

Highly efficient and scalable chemoenzymatic syntheses of (R)- and (S)-lactaldehydes

M. A. K. Vogel, H. Burger, N. Schläger, R. Meier, B. Schönenberger, T. Bisschops and R. Wohlgemuth, React. Chem. Eng., 2016, 1, 156
DOI: 10.1039/C5RE00009B

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