Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 107, 2016, Issue in Progress
Previous Article Next Article

Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications

Author affiliations

Abstract

Cryotropic gelation is a low cost, well-known technique that has been used for decades for the preparation of cryogels based on poly(vinyl alcohol). This technique does not require addition of any cross-linkers or initiators because a physical cross-linking takes place during the cryotropic gelation. Poly(vinyl alcohol)–Gantrez® AN cryogels with highly porous structure were successfully produced from the aqueous polymer mixtures with addition of 0.4, 0.6 and 0.8% w/v NaOH, which were frozen at −18 °C for approximately 9 hours and then thawed at room temperature (∼25 °C). These cryogels exhibited excellent mechanical properties (with 158–218% elongation to break) and high swelling ability in water (∼40 g of deionized water could be absorbed per 1 g of initial gel within 48 h). They exhibited intrinsic antimicrobial properties against Staphylococcus aureus without the addition of any antimicrobial agent due to the acidic nature of Gantrez® AN and related low pH of these cryogels. The in vitro biocompatibility of these cryogels was assessed using human dermal fibroblasts with very encouraging results. These cryogels are promising for applications in wound care.

Graphical abstract: Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Oct 2016, accepted on 27 Oct 2016 and first published on 28 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA24573K
Citation: RSC Adv., 2016,6, 105487-105494
  • Open access: Creative Commons BY license
  •   Request permissions

    Poly(vinyl alcohol)–Gantrez® AN cryogels for wound care applications

    E. Caló, J. Barros, L. Ballamy and V. V. Khutoryanskiy, RSC Adv., 2016, 6, 105487
    DOI: 10.1039/C6RA24573K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements