Issue 110, 2016

Hyalodendriellins A–F, new 14-membered resorcylic acid lactones from the endophytic fungus Hyalodendriella sp. Ponipodef12

Abstract

Six new 14-membered resorcylic acid lactones (RALs), named hyalodendriellins A–F (1–6), were isolated from the culture of the endophytic fungus Hyalodendriella sp. Ponipodef12 associated with the hybrid ‘Neva’ of Populus deltoides Marsh × P. nigra L. The structures of the new compounds were deduced by analyses of the NMR spectroscopic and mass spectrometry data, in combination with chemical conversion, modified Mosher's method and TDDFT ECD calculations for determining the absolute configurations. Compounds 1, 2, 4, and 6 possess a 3S configuration, while 3 and 5 are 3R-configurated. The co-occurrence of RALs with different stereochemistry at C-3 in the same fungus is rare. The CD behaviors of 1–6 as well as their acetonide and hydrogenated derivatives were investigated. All the isolated compounds were evaluated for their antinematodal, larvicidal, cytotoxic, antibacterial and antifungal activities. Among them, hyalodendriellin A (1) displayed moderate antinematodal activity against Caenorhabditis elegans and Meloidogyne incognita. Hyalodendriellin C (3) exhibited larvicidal effect against the fourth-instar larvae of the mosquito Aedes aegypti.

Graphical abstract: Hyalodendriellins A–F, new 14-membered resorcylic acid lactones from the endophytic fungus Hyalodendriella sp. Ponipodef12

Supplementary files

Article information

Article type
Paper
Submitted
27 Sep 2016
Accepted
01 Nov 2016
First published
07 Nov 2016

RSC Adv., 2016,6, 108989-109000

Hyalodendriellins A–F, new 14-membered resorcylic acid lactones from the endophytic fungus Hyalodendriella sp. Ponipodef12

D. Lai, Z. Mao, D. Xu, X. Zhang, A. Wang, R. Xie, L. Zhou and Y. Liu, RSC Adv., 2016, 6, 108989 DOI: 10.1039/C6RA24009G

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