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Issue 102, 2016
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Multicomponent synthesis of hydrazino depsipeptides

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Abstract

The Passerini reaction of α-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isostere. A wide range of carbonyl and isocyano components were used along the α-hydrazino acids carrying three different Nα protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different α-hydrazino acids were studied by DFT approach.

Graphical abstract: Multicomponent synthesis of hydrazino depsipeptides

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Article information


Submitted
19 Sep 2016
Accepted
08 Oct 2016
First published
12 Oct 2016

This article is Open Access

RSC Adv., 2016,6, 99664-99675
Article type
Paper

Multicomponent synthesis of hydrazino depsipeptides

J. Suć, D. Barić and I. Jerić, RSC Adv., 2016, 6, 99664
DOI: 10.1039/C6RA23317A

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